As a non-invasive modality, high intensity focused ultrasound (HIFU) ablation is receiving increasing interest for the local treatment of solid malignancies. The principle of this technique is that a high-energy ultrasound (US) beam can be focused at a distance from the radiating surface of transducer. The energy within the focal region can be sufficient to cook tissue and to induce necrosis of targets such as tumors, without causing damage to overlying or surrounding vital structures. The ability to cause cell death in a volume of tissue distant from the US source makes HIFU an attractive option for development as a noninvasive surgical tool. In clinical application, our previous randomized phase II clinical trial indicated that HIFU is safe, effective, and feasible in the treatment of localized breast cancer.
Pathologic findings revealed that HIFU-treated tumor cells underwent complete coagulative necrosis, and tumor vascular vessels were severely damaged. Immunohistochemical staining showed that HIFU-treated tumor cells lost the abilities to proliferate, invade and metastasize. However, it is essential to evaluate the long-term clinical results of HIFU treatment for patients with breast cancer.
In this study we report our preliminary follow-up results of HIFU in the treatment of 22 patients with breast cancer, and assess a possibility of using HIFU as a potential breast conserving modality. The purpose of this study was to determine patient acceptance of this non-invasive procedure, post-HIFU tumor regression, follow-up pathologic changes, cosmesis, local recurrence, and survival in these subjects. It was not our intention to compare HIFU with conventional breastconserving therapies for patients with breast cancer.
Soft tissue Sarcoma.
The soft tissues of the body include the muscles, tendons (bands of fiber that connect muscles to bones), fat, blood vessels, lymph vessels, nerves, and tissues around joints. Adult soft tissue sarcomas can form almost anywhere in the body, but are most common in the legs, abdomen, arms, and trunk.
There are many types of soft tissue sarcoma. One type that forms in the wall of the stomach, intestines, or rectum is called a gastrointestinal stromal tumor (GIST). The cells of each type of sarcoma look different under a microscope, based on the type of soft tissue in which the cancer began.
Benign breast neoplasm.
A benign breast tumor is an area of abnormal cell growth in the breast which is not considered to be cancerous. A very high percentage of breast lumps turn out to be benign, meaning that they should cause few or no health problems to the owner of the breast, but all breast lumps should be examined by a doctor to check for malignancies. Monthly breast self exams are strongly recommended for all women, so that changes in the breast tissue can be detected as early as possible. Mammograms for cancer screening purposes are also recommended for older women.
What are the key symptoms of uterine fibroids?
- Heavy and prolonged periods
- Bleeding between periods
- Lower back or leg pain
- Pain during sexual intercourse
- Need for frequent urination caused by bladder pressure
- Feeling of fullness in the lower abdomen